Dr Péter Lőw

 

 

Birth

24/04/1964, Budapest, Hungary

 

Marital state

married, wife: Helga Judit Borsos-Szabó, kindergarten teacher

four children: Márton (1991), Gergely (1993), Dorottya (1995), Julianna (1998)

 

Contacts

Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University

Pazmany Peter setany 1/C., Budapest, 1117 Hungary

(South Building) room 6-513

Phone: +36-1-372-2895

e-mail: peter.low@ttk.elte.hu

 

Education

Diploma:              Eötvös Loránd University, Faculty of Natural Sciences,

                             Biology major, 1988

PhD:                     Eötvös Loránd University, Faculty of Natural Sciences,

                             PhD in biology, 1995

                             thesis title: The effect of 20-hydroxyecdysone on the lysosomal and ubiquitin system of Sf9 insect cells

Habilitation:         Eötvös Loránd University, Faculty of Natural Sciences,

                             biological sciences, 2009

Language:            Russian – level B2, 1985

                             English – level C2, 1997

 

Work and positions

Eötvös Loránd University, Faculty of Natural Sciences,

Department of Anatomy, Cell and Developmental Biology (former Department of General Zoology)

 

1989 - 1991         scholarship holder for further scientific training

1991 - 1998         assistant lecturer

1998 - 2006         assistant professor

2006 -                  associate professor

2010 -                  head of department habilitated associate professor

 

Study trips

FEBS Biomolecular Electron Microscopy Advanced Course, Ulm, Germany, October 1989

TEMPUS Mobility Grant, University of Nottingham, Department of Biochemistry, Nottingham, UK, February - April 1992

Wellcome Trust International Travelling Research Fellowship, University of Bath, Department of Biology and Biochemistry, Bath, UK, August 1995 - July 1997

British Council Travel Grant, University of Bath, Department of Biology and Biochemistry, Bath, UK, February 1998

 

Prices and awards

HAS, Scholarship for further scientific training, 1989-1991

HCB, Research fellowship of the Foundation „For the Hungarian Science”, 1993

HAS, János Bolyai Research Scholarship, 1998-2001

Hungarian Electron Microscopic Award, 2001

György Békésy Postdoctoral Scholarship, 2001-2004

József Öveges Scholarship OMFB-01479, 2006-2007 

 

Research area

The role of apoptosis and autophagy in the programmed degradation of salivary gland of Drosophila

 

Grants as a PI in last 5 years:

Development of biosimilar monoclonal antibodies, NKFIH VKSZ_12-1-2013-0001, 2014–2017, 36 M HUF, Consortium leader: Gedeon Richter Ltd.; Consortium participant, Principal investigator

 

Analysing the role of Rab19 in autophagy and protein secretion; NKFIH K119971; 01-10-2016 – 30-03-2021; 24 M HUF; Consortium participant, Principal investigator

 

Grants as a co-worker in last 5 years:

Epigenetic role of ascorbate compartmentalization in human diseases; NKFIH FK124442; 01-12-2017– 31-08-2022; 40 M HUF; Principal investigator: Dr Éva Margittai, participant

 

Plumage colour signals: dynamic and static mechanisms; NKFIH K124443; 01-09-2017– 31-08-2022; 38 M HUF; Principal investigator: Dr Gergely Hegyi, participant

 

Endocytosis and degradation of the metastasis suppressor PMCA4b and its role in the lysosomal degradation program; NKFIH K135811; 01-09-2020 – 29-02-2024; 36 M HUF; Principal investigator: Dr Ágnes Enyedi, participant

 

Scientometric data

Full papers in journals with peer review: 34

Full papers in Hungarian journals with peer review, in English: 5

Book: 1

Book chapter: 3

Handbook: 3

Natural history papers: 38

Conferences: 43

Impact factor: 137.16

Citations: 2388

Hirsch-index: 19

 

Links to:

MTMT https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=authors10000294

Google https://scholar.google.hu/citations?hl=hu&user=RwP0c6IAAAAJ

Scopus https://www.scopus.com/authid/detail.uri?authorId=56141084700

Publons https://publons.com/researcher/1297118/peter-low

 

Teaching

BSc

Bioethics and Philosophy of Science L (bioetiub17em)

Animal Structure and Function 1 L (astfu1b17ea)

 

MSc

Mammalian-human tissue and organ development II. P (szszf2gb17lm)

Molecular Cell Biology L (molsbigb17em)

Programmed cell death and autophagy L (progspgb17em)

Bioethics and philosophy of science L (bioetiub17em)

Bioethics, biosafety L (bioetbb18em)

Neuroanatomy P (neuanahb17lm)

 

Biology teacher

Human Anatomy L (bb5t1400)

Bioethics L (bb5t1702)

 

PhD

Neuroanatomy P (BIO/06/07)

Molecular cell biology of autophagy, cellular degradation and renewal L (BIO/06/23)

 

Thesis work supervision

Péter Tarlós: The role of the ubiquitin-proteasome system in the larval muscle degradation of the Drosophila melanogaster (2005)

Zsófia Papp: Investigation of the mechanism of muscle breakdown in fruit fly (2007)

Ágnes Varga: The new role of the ubiquitin proteasome system: regulation of autophagy (2009)

Bernadett Bősze: Physiology of vision and visual illusions, BSc (2009)

Szabolcs Zödös: Ontogenetic Evidence of Evolution, Biology Teacher Supplement (2010)

Tamás Csizmadia: The role of the proteasome in cell signalling processes, BSc (2011)

Tamás Siller: The relationship between the ubiquitin-proteasome system and autophagy, BSc (2011)

Gyergyák Hella: Signalling processes-receptor tyrosine kinases, BSc (2012)

Eszter Gecse: The relationship between apoptosis and autophagy, BSc (2012)

Zoltán Kortsmáros: Bioethical issues in stem cell research, BSc (2012)

Oyinkan Mensah-Ogun: Ubiquitin-independent proteasomal degradation, BSc (2012)

Nagy Hajnalka: The proteasome as an antigen processing enzyme: the immuno-proteasome, BSc (2013)

Tünde Mónika Tóth: Tumours and apoptosis, BSc (2013)

Tamás Csizmadia: The role of autophagy in the degradation of Drosophila larval salivary glands during individual development, MSc (2013)

Ágnes Vadász: The role of the REP gene in the process of autophagy in Drosophila melanogaster, MSc (2013)

Gábor Kemenczei: The role of the ubiquitin-proteasome system in the regulation of transcription, BSc (2015)

Eszter Gecse: The role of the epg5 gene in autophagy in Drosophila melanogaster, MSc (2015)

Zsófia Hevesi: The role of the tank gene in autophagy in Drosophila melanogaster, MSc (2015)

Dankó Titanilla: Ubiquitin ligase (E3) enzymes as potential therapeutic targets, BSc (2016)

Gyenci Szenci: Selective autophagic degradation, BSc (2016)

Noble Barbara Dominika: Processes in the larval salivary gland of the vinegar during postembryonic development, BSc (2021)

Andrea Szathmári Csenge: Ubiquitin-like proteins in the regulation of autophagy, BSc (2021)

Kitti Szirmai: Health effects of trans fatty acids and their molecular background, BSc (2021)

Jamila Raufi: The role of autophagy in the function of stem cells, BSc (2022)

 

Supervision of project students in Scientific students’ association

Péter Tarlós: The role of the proteasome in the degradation of Drosophila larval muscles (2004) Eötvös University, Biology SSA, 3rd prize

Zsófia Papp: Investigation of the mechanism of muscle degradation in Drosophila dominant heat-sensitive mutants (2006)

Ágnes Varga: Is the ubiquitin proteasome system involved in the regulation of autophagy? (2007)

Tamás Csizmadia: The role of autophagy in the degradation of the Drosophila larval salivary gland during individual development (2012) Eötvös University, Biology SSA, 3rd prize

 

Supervision of PhD students

Tamás Csizmadia: Investigation of crinophagy in Drosophila larval and prepupal salivary glands (defence 2018)

Randa George Naffa (joint with Ágnes Enyedi): Intracellular trafficking and degradation of the metastasis suppressor PMCA4b in normal and tumour cells (defence 2021)

Szilvia Oláh (joint with Árpád Dobolyi): Investigation of neural networks involved in offspring care (proposed defence 09/2022)

Anikó Zsuzsanna Nagy (joint with Péter Lőrincz): Investigation of the role of ecdysone signalling in crinophagy in Drosophila larval salivary gland (proposed defence 12/2023)

 

BSc, MSc thesis topics

BSc

The role of the proteasome in cell signalling processes

The proteasome as an antigen processing enzyme: the immunoproteasome

 

MSc 

Investigation of possible connections between the ubiquitin-proteasome system and autophagy in Drosophila larval adipose tissue

 

The phenomenon already described in tobacco hawkmoth (Manduca sexta) is that proteins and proteasomes ubiquitinylated in the fat body that dies by autophagy in the last larval stage are transported to the nucleus. We would also like to monitor this phenomenon, which suggests that the proteasome plays a role in the management of autophagy, in vinegar. In different stages of wild and autophagy, defective mutant individuals are observed by immunocytochemistry to see whether ubiquitinated proteins and proteasomes enter the nucleus in the decaying adipose body. We examine whether the process occurs upon inhibition of various autophagy genes by RNAi. We will look at how this process takes place in mutants containing defective proteasomes and the effect of inhibiting the proteasome itself. Once adequate data on the phenomenon have been collected, nuclei are isolated from adipose body samples from the above experimental settings and an attempt is made to identify the target proteins to be degraded.

The task of the PD student is to maintain mutant strains, perform crosses, isolate adipose body samples, and perform light microscopic immunocytochemistry.

 

PhD topics

Investigation of the role of ubiquitin-proteasome system in the regulation of crinophagy in the larval salivary gland of Drosophila

 

The larval salivary gland of the fruit fly (Drosophila melanogaster) is totally degraded during development contributing to the material of adult tissues. The salivary gland of the feeding larvae produce saliva for the food digestion, later upon hormonal changes the larva starts wandering and the gland changes function: it starts to produce glue proteins to fix the pupa in a dry and safe environment. The gland cells do not empty all their secretory content the remnant should be eliminated. This is fulfilled with crinophagy, which is a special type of autophagy. We would like to clear the regulatory steps of this process during our research. The ubiquitin-proteasome system plays an essential role in the control of many cellular processes. We observe if crinophagy is completed upon the repression of the ubiquitin-proteasome system. We investigate on ultrastructural level if there are differences in the UPS mutants. The candidate have to take care of the mutant and transgenic fly stocks, to make crossings, isolate salivary gland samples and perform PCR, Western blot, light and electron microscopic experiments and immunocytochemistry. The detailed research plan will be completed upon discussions with the candidate.

 

Projects in Scientific students’ association

Investigation of the role of the EPG4 gene in autophagy in Drosophila melanogaster

 

Research

My research focuses on autophagy (intracellular self-digestion), within which I primarily examine crinophagy, its regulation, and its relationship to the ubiquitin-proteasome system. Malfunction of autophagy appears as a causal factor in the pathomechanism of many diseases or contributes to the development of the disease and the exacerbation of symptoms. Excessive crinophagy, for example, plays a role in excessive insulin degradation within β-cells that cause type II diabetes and early activation of pancreatic enzymes, leading to the development of acute pancreatitis. Our main goal is to explore the regulatory pathways of crinophagy, thus bringing us closer to understanding the pathomechanism of these diseases and thus more effectively treating diseases that occur mainly in gland cells with defective crinophagy.

 

Collaborations

Dr Judit Ovádi (HAS Institution of Enzymology) The role of cytoskeletal proteins and attached proteins in cell function

Dr Ágnes Enyedi (Semmelweis University, 2nd Department of Pathology) Intracellular trafficking and degradation of the metastasis suppressor PMCA4b in normal and tumour cells and its role in autophagy

Dr Árpád Dobolyi (Eötvös University, Department of Physiology and Neurobiology) Study of synapses of TIP39 fibres on dopaminergic neurons in the preoptic region of rat brain

Dr Miklós Csala (Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry) Cellular toxicity of dietary trans fatty acids and its correlation with ceramide and diglyceride accumulation

Dr Éva Margittai (Semmelweis University, Institute of Clinical Experimental Research) Epigenetic role of ascorbate compartmentalization in human diseases

 

Membership in scientific societies and boards

Hungarian Biochemical Society, 1989 –

Hungarian Biological Society, 1989 –

Hungarian Microscopic Society, 1990 –

HAS Public Assembly (11687), 1998 –

Secretary of Cell and Developmental Committee of HAS 2005 – 2011

Hungarian Biological Society, Zoological Section’s committee member, 2010 –

Chair of the Biology OKTV, 2011 –

Hungarian Society of Geneticists, 2013 –

 

Reviewer’s activity

     journals

Journal of Insect Physiology, 1998 –

Editorial board member of North-Western Journal of Zoology, 2005 –

Insect Biochemistry and Molecular Biology, 2011 –

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 –

Cells, 2017 –

Journal of Cellular Biochemistry, 2018 –

Nature Scientific Reports, 2018 –

International Journal of Molecular Sciences, 2019 –

Biomolecules, 2019 –

Autophagy, 2019 –

Journal of Molecular Sciences, 2019 –

Biochemical Journal, 2021 –

Biologia Futura – Guest Editor 2019, 2022

 

     grant proposals

OTKA, 2005, 2006

TéT, 2007, 2008

OTKA Infraindividual Biology committee member, 2012-14

Momentum Grants, 2013

 

Participation in the judging panels of scientific students’ competitions

Jury member of the 9th National Conference of Scientific Students’ Associations (2009) Cell Biology Section

Jury member of Conference of Biology Scientific Students’ Association, Eötvös University (2009) Cell Biology Section

President of the National High School Study Competition in Biology, from the 2011-12 academic year

Jury Chairman Conference of Biology Scientific Students’ Association, Eötvös University (2016) Genetics, Cell and Developmental Biology Section

Jury member Conference of Biology Scientific Students’ Association, Eötvös University (2018) Genetics and Cell Biology Section

 

University public activity

Secretary of the Institute of Biology, Eötvös Loránd University, 2001-2006

Elected member of the Council of the Institute of Biology of Eötvös Loránd University, 2009-2010

Substitute of General Council of the Committee of Legal Remedy for Students, 2009-

Proggins of the Disciplinary Committee of Eötvös Loránd University, Faculty of Natural Sciences, 2013-

Chair of the Animal Welfare Committee of Eötvös Loránd University, 2014-

Head of Molecular Cell and Neurobiology Program, Biology Doctoral School, Eötvös Loránd University, 2021-

 

Participation in scientific qualification procedures

Since 2002, I have participated in more than 85 doctoral and habilitation actions of Biology Doctoral School, Eötvös Loránd University, and Doctoral Schools of University of Szeged; University of Debrecen, Medical School; University of Pécs, Medical School and Semmelweis University, Budapest as an examiner or reviewer or as a secretary or member of the committee.